Audited Supplier
2381089-83-2
N/a
200-001-8
Synthesis Material Intermediates
Powder
Refined
White
Standard
Laboratory Reagents
Dry Powder
Fine Chemicals
Scientific Research
Research Peptides
No Tfa Salt
Authoried Regluar Workshop
1g/Bottle
Research Use Only
Hoconbio
Customized
1G/Bottle
China
Product Description
Larazotide acetate (LA) is a single-chain peptide of eight amino acids that acts as a tight junction regulator to restore intestinal barrier function. LA is currently being studied in phase III clinical trials and is orally administered to adult patients with celiac disease as an adjunct therapeutic to enhance intestinal barrier function that has been disrupted by gliadin-induced immune reactivity. Mechanistically, LA is thought to act as a zonulin antagonist to reduce zonulin-induced increases in barrier permeability and has been associated with the redistribution and rearrangement of tight junction proteins and actin filaments to restore intestinal barrier function. More recently, LA has been linked to inhibition of myosin light chain kinase, which likely reduces tension on actin filaments, thereby facilitating tight junction closure. Small (rodent) and large (porcine) animal studies have been conducted that demonstrate the importance of LA as a tight junction regulatory peptide in conditions other than celiac disease, including collagen-induced arthritis in mice and intestinal ischemic injury in pigs.
Making Larazotide Capsules
as S-Phenyl-Acetyl Larazotide and Sodium-Larazotide
+ Aloe Vera and Quercetin
+ Sodium Bicarbonate
| Product Name | Larazotide Acetate |
| CAS NO. | 881851-50-9 |
| Other name | N/A |
| Appearance | White powder |
| Purity | 98% HPLC |
| Application | Research peptides |
| Shelf Life | 24 Months |
| Storage | Store at a temperature of 2-8 degrees, protected from light. |
