High Quality Chinese Supplier Crystalline Powder CAS. 5080-50-2 Acetyl-L-Carnitine

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Changsha Nutra-Y Biotechnology Co., Ltd

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5080-50-2
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White Crystalline Powder
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Product Description


 

About this item

Acetyl L-Carnitine HCL Crystalline is a nutritional supplement that is a white to almost white powder or crystal. It is a form of the amino acid L-carnitine, which is produced in the body and found in some foods. Acetyl L-Carnitine HCL Crystalline is also known as ALCAR hydrochloride or O-Acetyl-L-carnitine hydrochloride. 

A nutritional supplement composed of the hydrochloride salt form of the acetylated form of the endogenously produced L-carnitine, with potential neuroprotective, cognitive-enhancing, anti-depressive and immunomodulating activities.





 

Function and efficacy


Acetyl L-carnitine hydrochloride (ALCAR) is a nutritional supplement that appears as a white, crystalline powder with a slightly acidic taste. It's used for a variety of purposes, including: 
 
 
  • Cognitive enhancement: May improve memory and thinking skills in older people 
     
     
  • Mood improvement: May help improve mood and decrease depression in some people 
     
     
  • Nerve pain: May help with nerve pain, such as tingling in the hands and feet 
     
     
  • Energy levels: May help improve appetite and increase energy levels 
     
     
  • Blood sugar: May help with cholesterol for people with high blood sugar 
     
     
  • Cell damage: May help stop cell damage 
     
     
  • Reproductive hormones: May improve hormone levels in women with low levels of female hormones 
     
     
  • Mental clarity: Some people find that it gives them noticeably better mental clarity 
 
Acetyl-l-carnitine might increase a brain chemical called serotonin. Some medications also have this effect. Taking acetyl-l-carnitine along with these medications might increase serotonin too much. This might cause serious side effects including heart problems, seizures, and vomiting.
 

Description

Acetyl-L-carnitine is a derivative of carnitine that enables functions of CoA and plays a significant role in the maintenance of energy homeostasis. Acetyl-L-carnitine exhibits antidepressant, neuroprotective, analgesic, and antinociceptive activities. In vivo, acetyl-L-carnitine acetylates p65, inducing NF-κB-mediated upregulation of mGluR2 receptors. In neuron-like PC12 cells, acetyl-L-carnitine inhibits 3-NPA-produced cellular stress responses and neurotoxicity. Acetyl-L-carnitine normalizes brain levels of neurotrophic factors such as NGF, GDNF, and artemin in animal models of neuropathy. Additionally, acetyl-L-carnitine exhibits some degree of antinociceptive benefit through indirect modulation of M1 muscarinic acetylcholine receptors (mAChRs). In cellular models of Alzheimer's disease, this compound also stimulates α-secretase activity and metabolism of amyloid precursor protein (APP).



L-Carnitine is an amino acid which has a role to play in the body's fat metabolism process. 
LCarnitine transports fatty acids to the mitochondria, which is where they are essentially burned as fuel. This amino acid naturally occurs, although it can also be biosynthesized from two other ones. In addition to being found in a wide range of foods, it is also commonly available as a dietary supplement. 

 
Fat Loss: L-carnitine transfers long chain fatty acids (e.g., triglycerides) into mitochondria, where they may be oxidized to produce energy. Carnitine has also been shown to relieve fatigue and act as an appetite suppressant.

Muscle Mass: L-carnitine is also a good weapon to seek strong muscle wraps. Replenishing L-carnitine can help you increase your strength, and heavier weight means longer muscles.

Bone Mass: By taking l-carnitine, you can slow down the bone loss process and improve bone micro structural properties by decreasing bone turnover.

Male Infertility: For those men who have been struggling to have children and have low sperm count, carnitine has been raised to help improve sperm count and sperm quality.

Immune System: L-carnitine can act as an antioxidant and can help prevent free radical damage to healthy cells. This can help you when you are cold or are dealing with all kinds of seasonal allergies and training.

Brain Function: L-carnitine helps protect the brain from both age related and stress related damage to the brain which helps it function longer and better.
 

About us

* The statements in this section have not been evaluated by the FDA or EFSA.
 

References


    1.Evans M, Sulley AM, Crowley DC, Langston J, Guthrie N.Nutrients. 2020 Jun 19;12(6):1831. doi: 10.3390/nu12061831.PMID: 32575480 
    2.Freddi R, Duca P, Gritti I, Mariotti M, Vertemati M.Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):419-26. doi: 10.1016/j.pnpbp.2008.12.021. Epub 2009 Jan 7.PMID: 19171177
    3.Ivica J, Adam F, Wortel L, Kalika T, Pelly H, Gauthier J, Potter M.Clin Biochem. 2024 Jan;123:110698. doi: 10.1016/j.clinbiochem.2023.110698. Epub 2023 Dec 2.PMID: 38048898
    4.Dubland JA, Rakić B, Vallance H, Sinclair G.J Mass Spectrom Adv Clin Lab. 2021 Mar 17;20:1-10. doi: 10.1016/j.jmsacl.2021.03.001. eCollection 2021 Apr.PMID: 34820666
    5.Gambi D, Onofrj M, Calvani M, Faricelli A, Del Re ML, Bazzano S, Cutarella R, Fulgente T, Colangelo U.Drugs Exp Clin Res. 1989;15(9):435-46.PMID: 2630254
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