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Citrus Nobilis Lour. Peel, C. Arantium L Lime.
Citrus Nobilis Lour. Peel, C. Arantium L Lime.
QINGYA
1kg/Bag, 25kg/Drum
10: 1
China
1302199099
Product Description
Physical and chemical properties of product
| Product Name: Polymethoxylated Flavones(PMFS) |
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| Plant source:Citrus nobilis Lour. Peel, C. arantium L lime. Fruit peel, citrus C. Ticulata Blanco leaves, stem extract. |
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| Product specifications:30% 40% 60% |
| Detection method: HPLC |
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| Physical properties: Reddish brown powder with a distinctive odor. |
| Solubility:Soluble in hot ethanol |
| Preservation method: Keep in a cool and dry place, away from light and high temperature |
Product overview
Polymethoxylated Flavones, PMFS is a kind of flavonoids containing multiple methyl groups, low polarity and plane structure with strong biological activity. It mainly comes from the citrus of Rutaceae and exists in orange peel, green peel, orange red, bergamot, trifoliate and other herbs. It has anti-cancer, anti-inflammation, anti-oxidation, anti-atherosclerosis, anti-allergy, inhibition of platelet aggregation and regulation of nerve center, anti-mutagenic and anti-mutagenic properties Cardiovascular and other pharmacological effects, so PMFS can be developed into drugs, health products, food additives, etc., it will have a good market prospects in the application of human anticancer agents, anti-inflammatory agents, anti-mutagenic agents and antioxidants, so it has potential anticancer drugs or functional food development value.
Polymethoxylated Flavones, PMFS is a kind of flavonoids containing multiple methyl groups, low polarity and plane structure with strong biological activity. It mainly comes from the citrus of Rutaceae and exists in orange peel, green peel, orange red, bergamot, trifoliate and other herbs. It has anti-cancer, anti-inflammation, anti-oxidation, anti-atherosclerosis, anti-allergy, inhibition of platelet aggregation and regulation of nerve center, anti-mutagenic and anti-mutagenic properties Cardiovascular and other pharmacological effects, so PMFS can be developed into drugs, health products, food additives, etc., it will have a good market prospects in the application of human anticancer agents, anti-inflammatory agents, anti-mutagenic agents and antioxidants, so it has potential anticancer drugs or functional food development value.
Advantages:
Stable and high-quality raw material sources. Mature and stable production process. The product solvent residue is qualified. A variety of product specifications are available. It can be stored for a long time in a cool, dry place and sealed away from light.
Extract safety:
As a food additive and plant extract, it is safe, non-toxic and harmless.
Efficacy:
1. Anti-cancer effect
Polymethoxy-flavonoids can induce Ca2+ -mediated apoptosis of breast tumor cells.
2. Anti-atherosclerosis
Polymethoxy-flavonoids in orange peel can inhibit the secretion of low-density lipoprotein and apolipoprotein in rat liver HepG2 cell population through various mechanisms.
3. Anti-inflammatory effect
Natural hydroxy-polymethoxy-flavones or the metabolites of tangerine and hesperetin have better anti-inflammatory activity than their polymethoxy-flavones counterparts. (5-hydroxy-3, 6, 7, 8,3 ', 4 '-hexamethoxyflavone),3', 4 '-dihydroxy-5, 6, 7, and 8-tetramethoxyflavone significantly inhibited the TPA-induced upward expression of induced-nitrogen oxide synthase (iNOS) and cyclocooxygenase-2 (COX-2), while PMFS was found to be superior to TPA(12-O-tetradecanoylphorbol-13-acetate) The expression of iNOS and COX-2 messenger RNA can be prevented after 30 min of topical administration, which indicates that PMFS is a new and good anti-inflammatory agent.
4. Antioxidant
All the four polymethoxy-flavone monomers in citrus peel had a certain ability to resist linoleic acid oxidation, natsudaidain and Nobily-TIN showed a strong ability to resist linoleic acid oxidation, Tangeretin showed the second. natsudaidain and Nobiletin also inhibited the oxidation of liposomes and scavenging of -OH free radicals.
5. Anti-mutagenesis
Three polymethoxy-flavones were isolated and identified from the dichloromethane extract of methanol extract of Citrus aurantium, which could inhibit all mutagenic factors, such as SOS reaction induced by furanyl glycoamide, at a concentration of 0.6 mol? In mL-1, the inhibition of gene expression was 67%, 45% and 25%, respectively.
6. Other functions
Patients with cardiovascular disease may be treated with effective doses of polymethoxy-flavones (including citretin derivatives, quercetin derivatives, naturally occurring polymethoxy-flavones, tocotrienols, and mixtures thereof) for the treatment of tanetin, hesperetin, 5-O-demeth-ylnobiletin, 5, 7, 8, 3 ', 4 '-pentamethoxyflavone showed antibacterial activity against both gram-positive and Gram-negative bacteria.
Storage :
Store in a cool, dry, dark, and high-temperature place.
Packaging :
Negotiate or use double-layer plastic bags, 1kg aluminum foil bags, and 25kg cardboard barrels internally.
Stable and high-quality raw material sources. Mature and stable production process. The product solvent residue is qualified. A variety of product specifications are available. It can be stored for a long time in a cool, dry place and sealed away from light.
Extract safety:
As a food additive and plant extract, it is safe, non-toxic and harmless.
Efficacy:
1. Anti-cancer effect
Polymethoxy-flavonoids can induce Ca2+ -mediated apoptosis of breast tumor cells.
2. Anti-atherosclerosis
Polymethoxy-flavonoids in orange peel can inhibit the secretion of low-density lipoprotein and apolipoprotein in rat liver HepG2 cell population through various mechanisms.
3. Anti-inflammatory effect
Natural hydroxy-polymethoxy-flavones or the metabolites of tangerine and hesperetin have better anti-inflammatory activity than their polymethoxy-flavones counterparts. (5-hydroxy-3, 6, 7, 8,3 ', 4 '-hexamethoxyflavone),3', 4 '-dihydroxy-5, 6, 7, and 8-tetramethoxyflavone significantly inhibited the TPA-induced upward expression of induced-nitrogen oxide synthase (iNOS) and cyclocooxygenase-2 (COX-2), while PMFS was found to be superior to TPA(12-O-tetradecanoylphorbol-13-acetate) The expression of iNOS and COX-2 messenger RNA can be prevented after 30 min of topical administration, which indicates that PMFS is a new and good anti-inflammatory agent.
4. Antioxidant
All the four polymethoxy-flavone monomers in citrus peel had a certain ability to resist linoleic acid oxidation, natsudaidain and Nobily-TIN showed a strong ability to resist linoleic acid oxidation, Tangeretin showed the second. natsudaidain and Nobiletin also inhibited the oxidation of liposomes and scavenging of -OH free radicals.
5. Anti-mutagenesis
Three polymethoxy-flavones were isolated and identified from the dichloromethane extract of methanol extract of Citrus aurantium, which could inhibit all mutagenic factors, such as SOS reaction induced by furanyl glycoamide, at a concentration of 0.6 mol? In mL-1, the inhibition of gene expression was 67%, 45% and 25%, respectively.
6. Other functions
Patients with cardiovascular disease may be treated with effective doses of polymethoxy-flavones (including citretin derivatives, quercetin derivatives, naturally occurring polymethoxy-flavones, tocotrienols, and mixtures thereof) for the treatment of tanetin, hesperetin, 5-O-demeth-ylnobiletin, 5, 7, 8, 3 ', 4 '-pentamethoxyflavone showed antibacterial activity against both gram-positive and Gram-negative bacteria.
Storage :
Store in a cool, dry, dark, and high-temperature place.
Packaging :
Negotiate or use double-layer plastic bags, 1kg aluminum foil bags, and 25kg cardboard barrels internally.
