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What is Biotin?
Biotin is one of the B vitamins, also known as vitamin H, vitamin B7, and coenzyme R. It is a necessary substance for synthesizing vitamin C and an indispensable substance for the normal metabolism of fats and proteins. It is a necessary nutrient for maintaining the natural growth, development, and normal functional health of the human body. It is abundant in the liver, kidneys, yeast, and milk and is an important factor for organisms to fix carbon dioxide. It is easy to bind to a protein in chicken protein, and consuming a large amount of raw protein can hinder the absorption of biotin, leading to biotin deficiency, such as hair loss, weight loss, dermatitis, etc. Biotin plays an important role in biochemical reaction pathways such as fat synthesis and glycogenesis.1. Prevent hair loss
2. Prevention of juvenile baldness
3. Maintain skin health
4. Has certain benefits for depression and insomnia
Grignard Reaction: Grignard reagent reacts with thioketones to form intermediates, which undergo elimination and rearrangement to generate ketenes, serving as important intermediates in organic synthesis.
Hydrogenation: Ketenes react with hydrogen gas in the presence of a catalyst, undergoing hydrogenation to reduce the carbon-carbon double bond and form corresponding alcohols, ethers, or amines as hydrogenation products.
Debenzylation: Suitable debenzylation reagents or catalysts are introduced to remove the benzyl groups from the hydrogenation products, leading to the formation of corresponding hydroxyl, amino, or thiol compounds, which are then transformed into B salts.
Cyclization: B salts undergo cyclization reaction through heating or the action of catalysts, resulting in the formation of crude D-Biotin structure, which requires further purification to obtain high-purity D-Biotin.
Refine: Through techniques like crystallization, solvent extraction, and chromatography, impurities are removed, and the crude D-Biotin is purified and concentrated to obtain high-purity D-Biotin.
Packing: Refined D-Biotin is accurately weighed and appropriately packaged and labeled to ensure product safety and stability. The finished D-Biotin is sold as pharmaceuticals, cosmetics, nutritional supplements, and other end products provided to consumers for use.
| Product name | D-Biotin | ||
| Test item(s) | Limit | Test result(s) | |
| Description and solubility | Practically white, crystalline powder.Very slightly soluble in water and in alcohol; insoluble in other common organic solvents. | Complies | |
| Identification: A.infrared absorption | To match with the reference IR spectrum | Complies | |
| B.Specific optical rotation | Meet the requirements | Complies | |
| C.HPLC | The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained In the Assay. | Complies | |
| Assay | 97.5%-102.0% | 99.0% | |
| Individual impurity | NMT1.0% | 0.04% | |
| Total impurities | NMT2.0% | 0.04% | |
| Optical Rotation | +89°-+93° | +90.4° | |
| Residual solvents(Toluene) | <890ppm | <20ppm | |
| Conclusion | Complies with standards. | ||
Baoding Faithful Industry Co., Ltd. was established in 2005 and is located in the National High Tech Industrial Science and Technology Park of Baoding City, Hebei Province. It specializes in researching, producing, and selling raw materials for health products. Its main products include sodium hyaluronate, collagen, trypsin, gastric enzymes, and plant extracts. Our products are exported to over 20 countries, including the Americas, Europe, and Asia. We have extensive markets and research centers in the United States, Germany, Japan, and other places and a vast database of cutting-edge skin biology that accurately captures global trends. The laboratory has senior engineers and high-end experimental equipment, pursuing ultimate scientificity and safety and meeting consumers' high requirements for quality of life. We have established a comprehensive service system from quality control and sales to after-sales service and have passed the ISO9001 quality management system. We will provide new and old cosmetics customers with higher quality products, higher quality, more complete, and more thoughtful services.
