Audited Supplier
Epithalon
6230
Chons
6230
Powder
Powder
Organic Chemical Material
Solid State
Pharmaceutical Intermediates
Powder
White
Janoshik
99%
Exceed Content
Yes
Janoshik
Yes
7-12days
Enjoy Free Second Payment for Customs Issues
Weight Loss
Cocer
Concealed Transportation
10mg
China
3001200010
Product Description
| Purity | 99%+ | Private customization | 2mg 5mg 10mg 15mg 20mg 30me etc. | |
| Cleanliness | Sterile | Transportation time | 7-15days | |
| Actual peptide content | Exceed the standard | Disguise | Can provide | |
| Test Report | Janoshik Test Report | Resend policy | According to different countries | |
| Customized top color | Red Yellow Blue Black Purple White Green | Payment method | Bank Transfer BTC USDT Paypal |
The renin-angiotensin system (RAS) is a paracrine RAS within the central nervous system (CNS) and is closely related to Alzheimer's disease (AD). The endogenous hexapeptide angiotensin IV (Ang IV), an important component of the brain RAS, was found to rescue cognitive impairment and recover memory in previous studies. In our study, we used different doses of Dihexa, which can be orally administered and cross the BBB in APP/PS1 mice. We found that the amount of AngIV in mouse tissue increased after the administration of Dihexa compared to that in the WT group. Meanwhile, Dihexa restored spatial learning and cognitive functions in the Morris water maze test. Dihexa increased the neuronal cells and the expression of SYP protein in APP/PS1 mice in Nissl staining. Furthermore, Dihexa decreased the activation of astrocytes and microglia, markedly reduced levels of the pro-inflammatory cytokines IL-1β and TNF-α and increased the levels of the anti-inflammatory cytokine IL-10. Dihexa activated the PI3K/AKT signaling pathway, while PI3K inhibitor wortmannin significantly reversed the anti-inflammatory and anti-apoptotic effects of APP/PS1 mice. These findings highlight the brain AngIV/PI3K/AKT axis as a potential target for the treatment of AD.
Peptides are composed of amino acids linked together by Peptides. The smallest Peptides can consist of three amino acids, such as thyrotropin-releasing hormone (TRH). Most Peptides can be made up of dozens or even hundreds of amino acids. The primary secretion organs for Peptides are the hypothalamus and the pituitary gland; however, Peptides have also been found in other organs, such as the gastrointestinal tract, brain tissue, lungs, and heart. Peptides are a type of endogenous substance that consists of protein chains containing polypeptide compounds. Examples of Peptides include thyrotropin-releasing hormone, Peptides and its analogs, Peptides and its analogs, adrenocorticotropic hormone, gonadotropins, Peptides and its analogs, Peptides-like Peptides, calcitonin, and parathyroid hormone.
The functions of Peptides include:
1:Growth Effects: They promote the division and proliferation of cells in bones, cartilage, muscles, and other tissues, leading to increased protein synthesis. This promotes bone growth during childhood and adolescence and is primarily used clinically for the treatment of dwarfism.
2:Metabolic Effects: They increase muscle mass and enhance tendon strength, resulting in stronger muscles and increased power, providing a competitive advantage. This is one reason why they are used as performance enhancers.
3:Anti-Aging Effects: They are frequently used in the field of cosmetics.
2:Metabolic Effects: They increase muscle mass and enhance tendon strength, resulting in stronger muscles and increased power, providing a competitive advantage. This is one reason why they are used as performance enhancers.3:Anti-Aging Effects: They are frequently used in the field of cosmetics.
1. How can I confirm the quality of the product before purchasing?
Answer: We can provide samples, and we have authoritative testing reports from the Janoshik laboratory.
2. Do you provide after-sales service after shipping?
Answer: Our customer service is available 24/7, and we will immediately assist you with any product issues, including shipping problems.
3. How long does delivery take?
Answer: It depends on your location; typically, the time is 7-12 days, which is the fastest logistics speed available.
4. What type of products do you mainly focus on?
Answer: Cocer Pharmaceutical has been specializing in peptide products for 30 years, focusing on the production of peptides in the health, fitness, weight loss, and beauty fields since 1990. All products have been tested by the Janoshik laboratory and come with detailed testing reports.
