Audited Supplier
SUREST-13
2156-56-1
C2HCl2nao2
218-461-3
Powder
Food Grade
150.92
198 ºC (DEC.)
Soluble in Cold Water
2 Years
Available
Surest
25kg or 200 Kg/Barrel
98%min
China
2915400090
Product Description
| Name | Sodium dichloroacetate |
| Molecular Structure | |
| Molecular Formula | C2HCl2NaO2 |
| Molecular Weight | 150.92 |
| CAS Registry Number | 2156-56-1 |
| EINECS | 218-461-3 |
| Melting point | 198 ºC (dec.) |
|---|---|
| Water solubility | soluble in cold water |
white crystalline powder, melting point 189-192ºC.
In vitro study:
Sodium dichloroacetate can induce apoptosis of human lung, breast and brain cancer cells. After Sodium dichloroacetate treatment, ROS levels in cancer cells increased, MMP depolarization, and apoptosis increased in vivo and in vitro. Sodium dichloroacetate inhibits the activity of pyruvate dehydrogenase kinase (PDK) and thus stimulates mitochondrial pyruvate dehydrogenase (PDH). When PDH is off, PDH no longer converts pyruvate to Chemicalbook acetyl-CoA (necessary for mitochondrial respiration and glucose-dependent oxidative phosphorylation processes). Thus, Sodium dichloroacetate converts cellular metabolism from glycolysis to glucose oxidation, reduces mitochondrial membrane potential, and promotes the opening of mitochondrial transport pores. This series of metabolic switches contributes to the translocation of pro-apoptotic mediators such as cytc and AIF. Therefore, Sodium dichloroacetate can drive cancer cells to commit suicide through apoptotic reaction.
In vivo study:
Sodium dichloroacetate acts as a cell growth inhibitor in vivo and in vitro without causing programmed cell death (apoptosis). Sodium dichloroacetate is a highly safe drug with no heart, lung, kidney or bone marrow toxicity. The most serious side effects include peripheral neuropathy, which is a reversible process. Sodium dichloroacetatehas anticancer activity in several cancer types, including colon, prostate, ovarian, neuroblastoma, lung, cervical, endometrial, cholangiocarcinoma, sarcoma, and T-cell lymphoma. Other antitumor effects of Sodium dichloroacetate have also been reported, including obstruction of angiogenesis, alteration of HIF-1α expression, alteration of pH regulators V-ATPase and MCT1, and alteration of other cell survival regulators such as PUMA, GLUT1, Bcl2, and p53. In a rat model of highly metastatic breast cancer, Sodium dichloroacetate can significantly reduce lung metastatic burden. In C57BL/6 mice, in vivo administration of Sodium dichloroacetate-Na induced a 20% improvement in survival and reduced tumor diameter, volume, and weight without affecting their weight and avoiding metastasis.
FAQ
Question 1: Can I get samples?
Answer: Yes,you can get free samples of our most products,
while the courier cost will be borne by the buyers.
Question 2: What's your MOQ?
Answer: For a express delivery order,the MOQ is usually 100 g~1 kg;
for an air transport order or sea delivery order ,the MOQ is usually 25 kgs.
Question 3: What's your delivery time?
Answer:
Orders shipped by express delivery,the delivery time is usually 5~7 working days;
Orders shipped by air transport,usually around 7~10 working days;
Orders shipped by sea , usually around 2~3 working weeks.
Question 4: What are the different payment methods?
Answer: We usually accept T/T, L/C and Western Union.
Question 5: How do you treat quality complaint?
We take quality very seriously, it is one of the founding principles of our business.
If the quality problem actually exists, we will replace with qualified goods or refund the money.
