1. Hypertension.
2. Angina.
PHARMACOKINETICS
After oral administration of therapeutic doses of levamlodipine besylate tablets, absorption produces peak plasma concentrations between 6 and 12 hours. Absolute bioavailability has been estimated to be between 64 and 90%. The apparent volume of distribution is 21L/kg, and with a terminal elimination half-life of about 30-50 hours. Steady-state plasma levels of amlodipine are reached after 7 to 8 days of consecutive daily dosing. Amlodipine besylate is extensively converted to inactive metabolites via hepatic metabolism with 10% of the parent compound and 60% of the metabolites excreted in the urine. Approximately 97.5% of the circulating drug is bound to plasma proteins.
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